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Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4See CONTRAINDICATIONSCombining these dual inhibitors with colchicine capsules in patients with renal and hepatic impairment has resulted in life-threatening or fatal colchicine toxicity.
Colchicine capsules are not an analgesic medication and should not be used to treat pain from other causes.
Patients with liver or renal impairment should be carefully monitored for adverse effects of colchicinesee section 5.2
Case reports and epidemiology studies in human male subjects on colchicine therapy indicate that infertility from colchicine is rareA case report indicated that azoospermia was reversed when therapy was stoppedCase reports and epidemiology studies in female subjects on colchicine therapy have not established a clear relationship between colchicine use and female infertility.
The treatment duration should be decided after factors such as flare frequencygout duration and the presence and size of tophi have been assessed.
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for patients who have just had their first attack, physicians may prescribe only medicine to reduce the pain and inflammation, such as non-steroidal anti-inflammatory drugs, corticosteroids or colchicine.