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Clonidine may potentiate the CNS-depressive effects of alcoholbarbiturates or other sedating drugsIf a patient receiving clonidine hydrochloride is also taking tricyclic antidepressantsthe hypotensive effect of clonidine may be reducednecessitating an increase in the clonidine doseIf a patient receiving clonidine is also taking neurolepticsorthostatic regulation disturbancese.gorthostatic hypotensiondizzinessfatiguemay be induced or exacerbated.

Tricyclic antidepressantsfor exampleamitriptylineElavilEndepimipramineTofranildesipramineNorpraminand clomipramineAnafranilcan block the blood pressure lowering effects of CatapresThis may cause blood pressure to rise.

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