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During treatment with this medicationyou must drink more fluids than usual and pass urine frequently to help avoid kidney and bladder side effectsAsk your doctor how much you should drink and how often to empty your bladder each dayand follow these instructions carefully.

To minimize bladder toxicityincrease normal fluid intake during and for 1-2 days after cyclophosphamide therapymost adult patients will require fluid intake of at least 2 L/dayhigh-dose regimens should be accompanied by vigorous hydration with or without mesna therapy.

Anaphylactic reactions have been reporteddeath has also been reported in association with this eventPossible cross-sensitivity with other alkylating agents has been reportedSIADHsyndrome of inappropriate ADH secretionhas been reported with the use of cyclophosphamideMalaise and asthenia have been reported as part of the postmarketing experience.

AdditiveCisplatin/etoposidefluorouracilhydroxyzinemethotrexatemethotrexate/fluorouracilmitoxantroneondansetron.

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