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You may develop lactic acidosisa dangerous build-up of lactic acid in your bloodCall your doctor or get emergency medical help if you have unusual muscle paintrouble breathingstomach paindizzinessfeeling coldor feeling very weak or tired.

Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabeteslowering both basal and postprandial plasma glucoseMetformin hydrochloride decreases hepatic glucose productiondecreases intestinal absorption of glucoseand improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Weaknessrespiratory tract infectionslow levels of vitamin B-12low blood glucoseheartburnand chills.

Before using this medicationtell your Order lotrisone online doctor or pharmacist your medical historyespecially ofkidney diseaseliver diseaseconditions that may cause a low level of oxygen in the blood or poor circulationsuch as severe congestive heart failurerecent heart attackrecent strokeserious infectionsevere loss of body fluidsdehydrationalcohol usesevere breathing problemssuch as obstructive lung diseasesevere asthmablood problemssuch as anemiavitamin B12 deficiencyelectrolyte imbalancehyponatremiafertility problemssuch as ovulation problemscertain hormonal conditionsadrenal/pituitary insufficiencythyroid diseasesyndrome of inappropriate antidiuretic hormone-SIADHa certain nervous system problemautonomic neuropathy

Metformin is negligibly bound to plasma proteins and isthereforeless likely to interact with highly protein-bound drugs such as salicylatessulfonamideschloramphenicoland probenecidas compared to the sulfonylureaswhich are extensively bound to serum proteins.

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