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The most commonly observed adverse reactions in CYMBALTA-treated patientsincidence of at least 5and at least twice the incidence in placebo patientswere nauseadry mouthsomnolenceconstipationdecreased appetiteand hyperhidrosis.
Serotonin syndrome or neuroleptic malignant syndrome-like reactions may occurdiscontinue and initiate supportive therapyclosely monitor patients concomitantly receiving triptansantipsychotics and serotonin precursors.
CYMBALTA treatment in placebo-controlled clinical trials across approved indicationswas associated with small mean increases from baseline to endpoint in ALTASTCPKand alkaline phosphataseinfrequentmodesttransientabnormal values were observed for these analytes in CYMBALTA-treated patients when compared with placebo-treated patientssee WARNINGS AND PRECAUTIONSHigh bicarbonatecholesteroland abnormalhigh or lowpotassiumwere observed more frequently in CYMBALTA treated patients compared to placebo.
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